What is Tadalafil?

Tadalafil, popularly known as the “weekend pill” is a prescription only drug used to treat Erectile dysfunction (ED). It is part of a group of drugs called phosphodiesterase-5 inhibitors, they work by relaxing the muscles around the arteries that supply the penis. This allows more blood to flow to the penis and allows easier and firmer erections when sexually aroused. 

Tadalafil is the longest acting ED drug of its kind with it staying active in your bloodstream for 36 hours. and allows for greater spontaneity in your sex life.

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Tadalafil is the active ingredient in the branded medication Cialis, it works by inhibiting the enzyme phosphodiesterase-5 and hence relaxes the smooth muscles around the blood vessels supplying the penis. This allows more blood to flow to the penis and allows for a stronger, easier erection that lasts long enough to enjoy good sex. 

Tadalafil is also sold in generic Tadalafil tablets which are equally as medically effective, have the same side effect profile and the same timeframe of action, however the generic Tadalafil tablets are cheaper than Cialis tablets of the same dose due to not being branded. 

How does Tadalafil work?

Tadalafil tablets work by relaxing the muscles around the blood vessels which supply the penis. They do this by inhibiting an enzyme called phosphodiesterase-5. The relaxation of these muscles allows increased blood to flow to the penis and allows for an easier spontaneous erection when aroused. 

How to take Tadalafil

The tadalafil 10mg tablet or 20mg tablet can be taken 30 minutes before planned sexual activity and you can expect the effects to last for the next 36 hours.

This does not mean that you will have a sustained erection for that time period, but that you will have more spontaneous erections when sexually aroused.

Tadalafil can be taken with or without food, but preferably should be swallowed whole with a glass of water.

Try not to take tablet Tadalafil with alcohol as that can increase the risk of side effects. 

Who should not use Tadalafil?

Tadalafil may not suitable for everyone, this medication should not be used or used in caution in individuals with certain medical conditions or taking specific other medicines.  These instances include:

• People taking nitrates such a Nitroglycerin, Isosorbide mononitrate or Glyceryl Trinitrate
• People with severe heart or blood pressure conditions such as uncontrolled hypertension or hypotension, or incidence of stroke (within 6 months), heart rhythm problems or severe aortic stenosis
• People with severe kidney or liver impairments which can cause problems with tadalafil excretion and lead to toxic buildups.
• People with allergic reactions to Tadalafil. 

How long does Tadalafil last?

Tadalafil stays active in the body for 36 hours, and is hence sometimes called the weekend pill, due to one pill’s effects of allowing you a spontaneous erection, whenever aroused, during the 36 hour time frame. The erection of course lasts only for a long enough time for you to enjoy good sex before allowing the penis to return to its normal state.

Tadalafil dosage

The dosage of Tadalafil depends on how it’s being used and for what purposes.

The as needed dose of Tadalafil is 10mg or 20mg and can be taken at least 30 minutes before sexual activity. The effects of the Tadalafil 10mg tablets last for 36 hours. 

The daily dose of Tadalafil can come in 5mg or 2.5mg tablets and can be taken daily to allow you to be ready for spontaneous sexual activity any time of the week. 

Side effects of Tadalafil

Like Most drugs Tadalafil also has some side effects, however they don’t affect everyone.

The most common side effects are:

• Headache
• Backache
• Muscle ache
• Indigestion
• Flushed Face

These side effects are mild in most people, and they wear off with continued use. If you feel that you cannot tolerate these side effects or they are prolonged then please speak to your healthcare provider. 

The following are serious side effects of Tadalafil, if you experience any of these, stop taking Tadalafil and seek medical attention immediately:

• Priapism: An erection that lasts for more than 4 hours, this is a medical emergency and must be tended to.
• Sudden loss of vision
• Sudden loss of Hearing
• Chest Pain
• Allergic reactions: Rashes, flushed face, swollen lips, tongue, face or palpitations 

Warnings and precautions for tadalafil

Tadalafil is generally considered a safe medication, however certain warnings and precautions may be considered to ensure it’s safe use:ё

• People with cardiovascular precautions such as a recent heart attack, a recent stroke (within 6 months), uncontrolled blood pressure or heart failure should not use tadalafil due to its potential effects of lowering blood pressure. 
• People taking nitrates (such as Glyceryl Trinitrate, Isosorbide Mononitrate or nitro-glycerine) should avoid using Tadalafil due to the severe drop in blood pressure that a combination of Tadalafil and nitrates can cause. 
• People using tadalafil should be watchful for a priapism, (a sustained and prolonged erection lasting for more than 4 hours), as these can be a medical emergency. 
• The usage of alcohol and tadalafil together can increase the risk of side effects, including priapisms. If you plan to drink alcohol while using tadalafil, please limit the alcohol intake to a maximum of 1-2 drinks. 
• Please also don’t take as needed a dose of the medication, tadalafil 10mg or 20mg on consecutive days or more than three times a week.
• If you have any known blood disorder such as Sickle cell anaemia, or Leukemia, or stomach disorders such as peptic ulcers or deformities of the penis, you should have an informed discussion with your healthcare provider before using Tadalafil. 

Please consult with your healthcare provider about any medical conditions you may have or medicines you may be taking to avoid any drug interactions with Tadalafil. 

Alternative erectile dysfunction medications

There are several alternative Erectile Dysfunction (ED) medications to Tadalafil and these include the following:

• Sildenafil (Viagra)

Also, a PDE-5 enzyme inhibitor that increases blood flow to the penis and allows for more spontaneous erections. It has a shorter duration of action than Tadalafil, around 4-6 hours.

• Vardenafil (Levitra)

Similar to sildenafil in mechanism of action and timeframe of activity

• Avanafil (Stendra)

Another PDE 5 enzyme inhibitor which gets active very quickly (within 15 minutes), but lasts for only 6 hours. 

Storage and Shelf Life of Tadalafil

To maintain the effectiveness and safety of your tadalafil pills, proper storage is essential. The medication should be kept in its original packaging, away from moisture and direct sunlight. Avoid storing it in humid environments like bathrooms, and always check the expiration date before use.

Recommended storage conditions:

• Store at room temperature (15–25°C)
• Keep away from heat and humidity
• Do not freeze or refrigerate
• Keep out of reach of children

If the tablets appear discolored or damaged, consult your pharmacist before taking them.

Can Women Use Tadalafil?

While tadalafil 10 mg tablets are approved for use in men with erectile dysfunction, research is ongoing regarding its potential benefits for women, particularly in treating certain circulatory or sexual dysfunctions. However, Tadalafil is not currently licensed for female use in the UK, and women should not take it unless specifically prescribed by a healthcare provider.

Always speak to a doctor before considering off-label use.

Where to Buy Tadalafil Online Safely

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Benefits of buying online:

• Fast 24-hour delivery across the UK
• Discreet packaging and secure payment
• Access to licensed medications
• No need for face-to-face consultations