Back To Top
Back To Top
Sandrena Gel is a Topical form of Hormone Replacement Therapy that uses the chemical hormone Estradiol to replace falling oestrogen levels during menopause. It is a prescription-only medication that can help soothe symptoms of menopause and, over time, provide bone protection from a post-menopausal state as well.
*Product images are for illustrative purposes only, and you may receive a different licensed alternative.
Price range: £28.99 through £71.99
You can now buy Sandrena Gel safely, securely and reliably online from Meds For Less and we will have it delivered to your home address within 24 hours.
Sandrena Gel is a hormone replacement therapy (HRT) medicine that contains the estradiol hormone. It is a prescription-only treatment used to treat the symptoms of menopause that arise as a result of declining oestrogen levels.
Sandrena is a topical application HRT gel that is applied to the skin and enters the bloodstream transdermally. The active ingredient used is Estradiol Hemihydrate – a synthetic form of the human oestrogen. This gel is usually applied to areas like the lower body or thighs and the estradiol is absorbed into the bloodstream. This raises levels of the hormone in the blood and helps combat the menopause symptoms.
Sandrena Gel is mostly used in HRT to treat symptoms or menopause such as:
In some cases, it can also be used to treat post-menopausal osteoporosis for certain women.
Please see your healthcare professional if you are experieicning menopausal or post-menopausal symptoms to see if Sandrena gel would be right for you.
The following is an overview of the different sandrena gel doses available for use:
Sandrena gel comes in the following dose formulations that delivers the hormone estradiol hemihydrate to the bloodstream transdermally. The doses can be:
The usual dose of Sandrena gel recommended by clinicians is 1.0mg, however sometimes the dose prescribed can range from 0.5mg to 1.5mg
It is usually applied to clean, dry skin on the lower body or thighs and allowed to absorb from skin into the bloodstream.
Please speak to your healthcare provider about the right dose of Sandrena gel for you. Doctors usually provide the lowest-effective dose of Sandrena for the shortest period of time.
Sandrena Gel is a form of Trandermal Hormone Replacement Therapy (HRT) that uses the chemical- Estradiol (a synthetic and identical formulation to Oestrogen) to replace falling Oestrogen levels in the body during menopause.
Sandrena uses Estradiol hormone in an alcohol based formulation, hence when the alcohol based gel is applied directly onto the skin, it is absorbed straightaway into the bloodstream.
Once the hormone is absorbed into the bloodstream, the estradiol is released over time and stable hormonal levels are gradually preserved in the body.
Because this form of HRT is not taken orally, it bypasses the liver and subsequent metabolism, hence reducing the risk of certain side effects (such as blood clotting).
Increasing the body’s oestrogen levels with this form of HRT helps relieve symptoms of menopause, such as:
If this form of oestrogen-only HRT is being used in women who still have a uterus (have not had a hysterectomy), then supplementary progesterone will also be required to protect the uterine lining and reduce any risks of endometrial hyperplasia.
The following is an overview of how to use Sandrena gel effectively and safely:
Like all hormonal medications, there are some side effects and precautions to be taken with Sandrena gel use.
Sandrena gel use has common, rare and serious side effects. Common side effects tend to be mild and disappear with continued use. Moderate and more serious side effects tend to be rare.
Common but mild side effects of Sandrena gel use include:
Less common side effects tend to include:
Dizziness
Slight and temporary mood changes (anxiety and irritability)
Changes in libido
Irregular breakthroughs and vaginal bleeding (in the first few months)
Rarer and serious side effects:
If any of these occur, please stop using Sandrena gel and seek medical help immediately:
Women who still have a womb (Have not had a hysterectomy) should use progesterone supplementation alongside Sandrena to prevent endometrial hyperplasia (womb lining thickening) and reduce the risk of endometrial cancer.
Using oestrogen therapies such as Sandrena can predispose people to oestrogen-based cancer, such as Breast Cancer. Please attend regular reviews with your healthcare professionals so they can conduct health checks and make sure you stay in good health.
The risk of serious side effects such as a blood clot or stroke is much lower using topical oestrogen treatment like Sandrena over oral HRT options. However, it is still worthwhile to have yourself checked regularly by your doctor to ensure your continued good health.
Sandrena Gel is a suitable HRT option for people who want to use oestrogen. The following is an overview of how can use Sandrena HRT and who it might not be suitable for:
Sandrena gel may be suitable for the following individuals:
Women who still have a womb (uterus) should use sandrena gel with progesterone to protect the endometrial lining.
Sandrena gel may not be suitable for the following individuals:
If you have any questions/ concerns about using Sandrena and whether it’s suitable for you – please speak to your healthcare provider.
Please find below the Sandrena Gel Prices as sold by Meds For Less UK:
Table 1: Please find below the prices of Sandrena gel as per the dosages and pack sizes
| Sandrena Gel dosage | No. of Sachet packs | Price | ||
| Sandrena Gel 0.5 mg | 1 pack of 28 sachets | £29.99 | ||
| Sandrena Gel 0.5 mg | 2 packs of 28 sachets | £54.99 | ||
| Sandrena Gel 0.5mg | 3 packs of 28 sachets | £69.99 | ||
| Sandrena Gel 1mg | 1 pack of 28 sachets | £29.99 | ||
| Sandrena Gel 1mg | 2 packs of 28 sachets | £54.99 | ||
| Sandrena Gel 1mg | 3 packs of 28 sachets | £69.99 | ||
Sandrena Gel can be used effectively and safely alongside other HRT treatments but only in certain clinically approved combinations. The following is an overview of some of the ways that Sandrena can be combined with other HRT options.
Common and safe HRT combinations include:
Please see your healthcare provider about safe and effective Sandrena and HRT combinations to use together. They can advise you on combinations that are safe or that may not be safe.
Sandrena HRT gel does not work instantly, but most people notice improvements fairly quickly when treatment begins. The following is an overview of what to expect for Sandrena gel and it’s timeline of action.
Within the first 1-2 weeks:
Early improvements such as:
Within 3-4 weeks of Sandrena use:
Significant improvements in the following symptoms:
Most Symptoms improve by this time , if they haven’t – please consult your healthcare provider to review your dose.
Within 2-3 months of Sandrena gel continuous use:
If you find that consistent and proper HRT gel Sandrena use is not having an effect to relieve your symptoms, speak to your clinician about adjusting your dose or trying another form of HRT.
Sandrena Gel does not cause weight gain or weight loss as a side effect of it’s treatment and most evidence-based research around Sandrena (and other forms of HRT) shows that it’s effects are weight-neutral. Changes in weight around the time you are applying Sandrena maybe due to ageing and lifestyle factors, but not the treatment
Sandrena gel (Oestrogen therapy) does not cause true weight gain through retention of excess fat tissue. Weight changes during menopause are linked to:
However, due to being an oestrogen-based therapy, Sandrena can cause fluid retention and bloating. These effects, however, are short-term and dose-dependent. Sandrena – being a transdermal therapy can also reduce the effects of oestrogen-based bloating that occurs with other oral HRT options.
Sometimes Sandrena gel can make it easier to loose weight indirectly. The ways it can do this include:
Improving sleep
Improving energy levels
Improving joint comfort
These effects can make it easier to stay active and maintain muscle mass and hence prevent mid-life weight gain.
Please speak to your healthcare provider about Sandrena gel weight gain or Sandrena gel weight loss.
Sandrena gel can be applied before bed, and this works well for many people as it easily allows for once daily dosing at a specific time each day.
The estradiol in Sandrena is absorbed transdermally through the skin directly into the bloodstream over several hours to maintain a consistent level of Oestrogen in the body. Hence, applying it before bed is safe and effective.
Applying Sandrena gel before bed can be particularly effective if you relate to the following experiences:
Sandrena Transdermal Gel is a safe and effective HRT option for long-term use in most people, as long as it is appropriately prescribed and reviewed.
Sandrena gel tends to be safer than some other forms of systemic HRT (such as oral) as it is directly absorbed into the bloodstream through the skin. This bypasses metabolism via the liver, lowers the risk of stroke and blood clots compared to oral oestrogen and provides more stable levels of female hormones
There is no fixed or maximum limit on safe Sandrena gel use. Most people use it for 5-10 years, and some even use the gel indefinitely. The important factor is to regularly watch for side effects and attend your follow-up appointments with your doctor to ensure your good health.
Most healthcare providers recommend annual check-ups with patients on Sandrena to ensure continued good health and to avoid developing any adverse side effects.
If you miss a dose of Sandrena gel, do not worry, it is not normally a serious issue, and this is how you can manage the situation.
If less than 12 hours have passed since the time you should have taken your Sandrena dose:
If more than 12 hours have passed since the time you should have taken your Sandrena dose:
Sometimes, missing one dose can cause symptoms such as:
While missing occasional doses is unlikely to cause much more than a temporary disruption in hormonal cover. If you find that menopausal symptoms have returned and are causing you trouble or that you have been frequently missing doses, please speak to your healthcare provider.
The falling oestrogen levels during menopause can cause sleep disruption and frequent mood swings. These are sometimes seen as unfortunate consequences of menopause.
Sandrena gel improves mood and sleep quality back to normal levels as it replaces oestrogen in the body through a steady and body-friendly way.
Sandrena gel allows the chemical hormone (estradiol) to be introduced into the body’s bloodstream directly through the skin. Estradiol is chemically identical to oestrogen and hence raises the effect of oestrogen in the body. Sandrena use brings hormonal balance, which reduces anxiety, irritability, mood swings, and brain fog.
The overall effect of Sandrena gel use is to restore sleep quality and help stabilise mood through hormonal stabilisation.