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Amitriptyline is a tricyclic antidepressant used to treat several conditions. It’s most commonly used to treat neuropathic pain or as a preventative migraine treatment.
Branded versions of the medication are rarely used in the UK nowadays. There are several pharmaceutical companies that manufacture for the UK market including accord amitriptyline, teva amitriptyline, crescent amitriptyline and lots of others.
Amitriptyline is a tricyclic antidepressant (TCA) with a moderate therapeutic index – It’s used to treat several conditions such as nerve pain, depression, and migraine prevention treatment.
Accord is one of several pharmaceutical companies that manufacturers Amitriptyline for the UK market. The active ingredients and in Accord Amitriptyline tablets are identical to that found in other generic versions of the medication meaning the therapeutic effect, quality and clinical performance are medically equivalent.
To ensure the treatment is effective, it is important to follow a gradual dosing schedule. This allows your body to adjust to the amitriptyline drug, reducing the risk of initial side effects. Most patients start with a low amitriptyline 10mg dose, taken once daily in the evening.
For the best results, swallow each pill whole with a glass of water. It is recommended to take it approximately 30–60 minutes before sleep, as the sedative effect helps with rest but can cause drowsiness if taken during the day. Whether you are managing chronic pain or depression, consistency is key to the success of the medication.
Amitriptyline can treat severe conditions. It’s most commonly used to treat pain, where the root cause of pain is related to a nerve (known as neuralgia.) This type of pain is unlikely to be alleviated using over-the-counter painkillers such as Paracetamol. Amitriptyline can also be used to manage other types of chronic pain.
Amitriptyline can also improve quality of life for patients suffering with other conditions such as migraines or depression however for these conditions there are typically other preferred first-line treatments.
As a preventive migraine treatment other medications may be preferred such as beta-blockers, antiepileptics or CGRP inhibitors.
Whilst Tricyclic antidepressants such as Amitriptyline were widely used in the past to treat depression nowadays SSRIs are usually preferred first-line treatments examples include Sertaline, Fluoxetine or Citalopram.
The appropriate dose of Amitriptyline depends on the condition being treated and the patient’s individual response to the medication. It is available in several strengths, with 10mg and 25mg tablets being the most common for starting treatment.
Patient Group / Condition | Typical Starting Dosage | Administration Notes |
Adults (Depression) | 75 mg daily in divided doses | Can be increased to 150 mg if needed |
Nerve Pain & Migraine | 10 mg to 25 mg once daily | Usually taken in the evening or at bedtime |
Geriatric Patients | 10 mg (3 times daily) | Includes an additional 20 mg dose at bedtime |
Pediatrics (12+ years) | 10 mg (3 times daily) | 20 mg dose at bedtime; monitored carefully |
It is important to note that the full therapeutic effect of Amitriptyline 10mg or higher doses may take up to 30 days to develop. Dosage adjustments should only be made by a healthcare professional based on clinical response and tolerability. If you are using the oral liquid form, always use a medical syringe for precise measurement rather than a kitchen spoon.
Consistency is vital for recovery, but if you forget a dose, take it as soon as you remember. However, if it is nearly time for your next application, skip the missed one. Never take a double dose to compensate for a forgotten pill.
An overdose is a serious medical emergency. If you suspect you have taken too much of this amitriptyline drug, contact emergency services immediately. Symptoms requiring urgent attention include:
Always keep your medication in its original packaging and out of reach of children to prevent accidental ingestion.
Antidepressants may increase the risk of suicidal thinking and behavior in children, adolescents, and young adults (under 24). Medical monitoring is required for at least the first 12 weeks of treatment.
Consult your doctor before use if you:
Keep out of the reach and sight of children. Read the enclosed leaflet before taking.
When ordering your prescription through a digital pharmacy, ensuring the source is reputable is the first priority. In the UK, legitimate medication must be dispensed by GPhC-regulated providers and arrive with an official dispensing label attached to the packaging.
You should exercise caution when browsing online, as unregulated companies often distribute counterfeit or unlicensed treatments. Before completing a purchase, always verify a provider’s reviews. Using unverified products can be ineffective or even pose a risk to your health, so prioritizing safety over convenience is essential for any patient.
The active substance in the tablets is amitriptyline hydrochloride, with each tablet containing either 10 mg, 25 mg, or 50 mg of the active ingredient. The other ingredients include lactose monohydrate, microcrystalline cellulose (E460), maize starch, colloidal anhydrous silica, magnesium stearate, hypromellose (E464), titanium dioxide (E171), and macrogol. Additionally, the 10 mg tablet contains indigo carmine (E132). The 25 mg tablet includes talc (E553b), quinoline yellow (E104), iron oxide (E172), sunset yellow (E110), and indigo carmine (E132). The 50 mg tablet contains talc (E553b), quinoline yellow (E104), and iron oxide (E172). For further details refer to the Amitriptyline PIL.