Co-cyprindiol and Adapalene Gel

For women with acne, a combination of Co-cyprindiol (also known as Dianette or Clairette) and Adapalene gel (generic Differin) can help to minimise the look and production of acne.

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Women should begin taking co-cyprindiol (also known as Dianette or Clairette) on the first day of their period and continue for 21 days before taking a 7-day break. Co-cyprindiol can be used as a contraceptive as well as a treatment for acne if taken carefully. Adapalene gel (generic Differin) should be used in conjunction with Co-cyprindiol, and a thin coating of the acne therapy should be applied to the affected area every day.

You should take the pill at the same time every day and apply Adapalene gel every night to get the most out of your acne treatment.

The combination of Co-cyprindiol, a contraceptive pill, and Adapalene gel, a topical acne treatment, tackles acne from two perspectives.

Co-cyprindiol is a combination of cyproterone and ethinylestradiol that helps to prevent acne by blocking the hormones that produce it.

Adapalene gel is a retinoid that works to reduce acne redness and irritation. It unclogs pores and minimises the appearance of blackheads and whiteheads.

The two-pronged action of this combination treatment means that it can be very effective in treating acne.

This combination is particularly effective for those who experience comedogenic acne (blackheads and whiteheads) and small red, sore spots called papules. It can take 4 to 12 weeks before you start to see any change to your skin.

Some women who take Co-cyprindiol may develop nausea, weight gain, headaches, mood swings, and breast discomfort. Adapalene gel can cause dry skin, irritation, burning, and redness in the afflicted area.

See the patient information booklets for Co-cyprindiol and Adapalene gel for a complete list of adverse effects and how to use them correctly.

While pregnant or breastfeeding, neither Co-cyprindiol nor Adapalene gel should be used.