Co-cyprindiol and Adapalene Gel


For women with acne, a combination of Co-cyprindiol (also known as Dianette or Clairette) and Adapalene gel (generic Differin) can help to minimise the look and production of acne.

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About Co-cyprindiol and Adapalene Gel

How do I take Co-cyprindiol and Adapalene gel?

Women should begin taking co-cyprindiol (also known as Dianette or Clairette) on the first day of their period and continue for 21 days before taking a 7-day break. Co-cyprindiol can be used as a contraceptive as well as a treatment for acne if taken carefully. Adapalene gel (generic Differin) should be used in conjunction with Co-cyprindiol, and a thin coating of the acne therapy should be applied to the affected area every day.

You should take the pill at the same time every day and apply Adapalene gel every night to get the most out of your acne treatment.

How does this combination acne treatment work?

The combination of Co-cyprindiol, a contraceptive pill, and Adapalene gel, a topical acne treatment, tackles acne from two perspectives.

Co-cyprindiol is a combination of cyproterone and ethinylestradiol that helps to prevent acne by blocking the hormones that produce it.

Adapalene gel is a retinoid that works to reduce acne redness and irritation. It unclogs pores and minimises the appearance of blackheads and whiteheads.

Is Co-cyprindiol and Adapalene in combination effective?

The two-pronged action of this combination treatment means that it can be very effective in treating acne.

This combination is particularly effective for those who experience comedogenic acne (blackheads and whiteheads) and small red, sore spots called papules. It can take 4 to 12 weeks before you start to see any change to your skin.

Are there any Adapalene or Co-cyprindiol side effects?

Some women who take Co-cyprindiol may develop nausea, weight gain, headaches, mood swings, and breast discomfort. Adapalene gel can cause dry skin, irritation, burning, and redness in the afflicted area.

See the patient information booklets for Co-cyprindiol and Adapalene gel for a complete list of adverse effects and how to use them correctly.

Is Adapalene safe to use when pregnant or breastfeeding?

While pregnant or breastfeeding, neither Co-cyprindiol nor Adapalene gel should be used.

Is there a chance that this treatment will interfere with other medications?

Topical acne treatments can be used in conjunction with Adapalene gel, but they must be administered at different times and must not contain tretinoin, isotretinoin, or tazarotene.

Other drugs may interfere with Co-effectiveness cyprindiol’s and capacity to prevent pregnancy. You should tell us about any other medications you’re taking so that we can safely prescribe the best acne therapy for you.

Acne Alternative Treatments

You may be administered oral antibiotics in addition to a topical gel or cream to treat your acne instead of the contraceptive pill Co-cyprindiol. Topical medicines can also be used on their own.

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