How Does Sumatriptan Work?

how does sumatriptan work

Written by Jan Davies • Last Updated: 06-05-2024


What Is Sumatriptan?

Sumatriptan is a medication that provides relief for migraine sufferers. It’s part of a group of drugs called triptans. Triptans work by imitating serotonin (5 HT), a chemical in the brain that can affect blood vessels and pain pathways. Sumatriptan helps by narrowing blood vessels in the brain that have become too wide during a migraine, which can reduce pain and other migraine symptoms like nausea and sensitivity to light or sound.

This drug is a focused treatment option, specifically targeting migraine symptoms, which makes it more effective for many people compared to general painkillers. It comes in different forms such as pills, sprays, or injections, so patients can choose the best method for their needs.

While sumatriptan is a popular choice for stopping migraines as they start, it’s not a cure for the condition. Patients with heart problems need to be cautious because sumatriptan can affect blood flow. It’s always important to talk to a doctor before starting sumatriptan to make sure it’s safe and suitable for an individual’s health needs. Additional Information: “Who can and cannot take Sumatriptan – NHS UK”.

What Is Sumatriptan used for

The effectiveness of Sumatriptan is most pronounced in the treatment of migraine attacks. Not only does it ease the pain, but it also combats the common accompaniments of a migraine such as nausea, and sensitivity to light and sound. It’s important to remember that Sumatriptan is not a prophylactic agent but rather a reactive treatment to be used when symptoms surface.

How many Sumatriptan can I take a day?

Navigating the dosage of Sumatriptan is a critical aspect of managing migraines effectively. Here are the steps to follow for optimal dosing:

1. Initial Dose: Begin treatment with a standard dose of Sumatriptan 50mg (for adults aged 18-65) at the onset of a migraine attack. This initial dose aims to kickstart the relief process and alleviate the intense symptoms experienced during a migraine episode.

2. Observation Period: After taking the initial dose, it is essential to monitor your symptoms closely. Allow sufficient time for the medication to take effect and observe how your body responds to the treatment.

3. Assessing the Need for a Second Dose: If the migraine symptoms persist or resurface after a period of time, you may consider taking a second dose of Sumatriptan. However, it’s crucial to wait at least 2 hours after the initial dose before considering a second dose.

4. Caution in Dosage: When contemplating a second dose of Sumatriptan, it’s vital to exercise caution and not exceed a total of 200mg within a 24-hour period. Adhering to the recommended dosage limits helps prevent potential side effects and ensures the safe and effective use of the medication.

5. Consultation with Healthcare Provider: Consulting with your healthcare provider before adjusting your dosage is imperative. They can provide personalized guidance based on your medical history, current health status, and the severity of your migraines. Your healthcare provider can offer valuable insights to optimize the dosage regimen and ensure safe usage of Sumatriptan.

By following these steps and seeking guidance from your healthcare provider, you can navigate the dosage of Sumatriptan with precision, ensuring effective relief from migraine symptoms while prioritizing your overall health and well-being. Additionally, you can always refer to the patient information leaflet for more information.

How to take Sumatriptan


The administration of Sumatriptan tablets is straightforward—take with water at the onset of migraine symptoms for best results. Food is optional but may aid those with nausea. It’s essential to consume the tablet whole unless advised otherwise by a healthcare professional.

When to Take Sumatriptan


Timing is crucial with Sumatriptan. The golden rule is to administer it at the first hint of a migraine to maximize its therapeutic potential. Procrastination in taking the medication can diminish its effectiveness, so prompt action is advised.

Side Effects of Sumatriptan

Sumatriptan, like any medication, can have side effects. Common side effects of sumatriptan may include:

1. Mild tingling or numbness
2. Dizziness
3. Warmth or redness under the skin
4. Pressure or heavy feeling in any part of the body
5. Muscle pain

Less common side effects that may occur include:

1. Chest pain or tightness
2. Irregular heartbeat
3. Shortness of breath
4. Severe or persistent abdominal pain
5. Changes in vision

It’s important to consult a healthcare provider if you experience any severe or persistent side effects after taking sumatriptan.

You should not take Sumatriptan if:

Sumatriptan may not be suitable for everyone. Individuals who fall into the following categories should avoid taking sumatriptan without consulting a healthcare provider:

1. Those with a history of heart disease, heart attacks, or strokes.
2. Individuals with uncontrolled high blood pressure.
3. People with peripheral vascular disease.
4. Those with a history of hemiplegic or basilar migraine.
5. Individuals with severe liver disease.

It is crucial to discuss your medical history and current health conditions with a healthcare provider before starting sumatriptan to ensure it is safe and appropriate for you. Always refer to section 6 of the patient information leaflet for more information regarding this question.

Can You Take Paracetamol with Sumatriptan

Taking paracetamol (also known as acetaminophen) with sumatriptan is often considered a safe combination for the treatment of migraine symptoms. Paracetamol is a widely-used pain reliever and fever reducer. When used in conjunction with sumatriptan, it may provide an added benefit by enhancing overall pain control. This can be particularly helpful because while sumatriptan targets the specific mechanisms of migraine pain, paracetamol works through a different pathway to relieve pain and reduce fever, offering a complementary effect.

However, it’s important to approach the combination of any medications with caution. Every individual’s health situation is unique, and what is safe for one person might not be for another. Factors such as existing health conditions, current medications, and the severity of migraine symptoms can influence the appropriateness of taking paracetamol and sumatriptan together.

Before starting this combination, it is crucial to consult with a healthcare professional. A doctor or pharmacist can provide personalized advice based on your health history and can ensure that the combination is suitable for you. They can also recommend appropriate dosages and timing for taking both medications to maximize the benefits and reduce the risk of side effects. Additionally, you can use a drug interaction checker to check if Sumatriptan interacts with any desired medications you wish to take.

Sumatriptan Dosage


The dosage of Sumatriptan is typically personalized, it is available in Sumatriptan 50mg and 100mg. Depending on individual response and medical history, physicians may adjust the dosage accordingly. It’s crucial to adhere to your prescribed dosage and not to self-medicate beyond the recommended limits. You can safely order sumatriptan online here at MedsforLess, after completing a short-text based consultation with one of our doctors.

Sumatriptan Alternatives

For those who find Sumatriptan unsuitable or ineffective, numerous alternatives are available. At Meds for Less, we have an extensive range of products on our Migraine Products & Treatments to suit individual needs. We recognize that each medication is tailored to each person, which is why we offer such a diverse selection. For example, if you prefer a soluble tablet, Solpadeine Plus is a perfect option. Alternatively, if you’d prefer a milder option, why not try Nurofen?  Some patients might benefit from different active ingredients in their migraine pills, or from preventative treatments if they experience frequent migraine episodes.

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