Do not take Adipine if you are allergic to nifedipine, other calcium-channel blockers  (e.g. verapamil, diltiazem, or felodipine), or any of the other ingredients in Adipine. Avoid it if you are pregnant, likely to become pregnant, or are breastfeeding. Additionally, refrain from taking Adipine if you have been diagnosed with a narrowing (stenosis) of the aortic valve in your heart, experienced a collapse caused by a heart problem (cardiogenic shock), or if the severity or frequency of your angina has rapidly worsened over a matter of hours or days. It should not be used to treat an angina attack as it occurs, but rather to reduce the frequency of angina over time. Avoid Adipine if you suffer from inflammation of the bowel or intestines (such as Crohn’s disease), have had an obstruction or narrowing of the intestine in the past, or have liver disease. Do not take it if you have had a heart attack during the last month or to treat a heart attack. Avoid Adipine if you are taking the antibiotic rifampicin (used to treat tuberculosis), if your blood pressure continues to rise despite treatment (malignant hypertension), or if you have a Kock pouch (a type of ileostomy). For further information refer to the Patient Information Leaflet

Before starting treatment, inform your doctor or pharmacist if you are taking or have recently taken any other medicines, including those obtained without a prescription. Notify healthcare providers if you are undergoing any medical procedures, especially if anaesthesia or surgery is involved. Inform your doctor if you are taking other medications to manage high blood pressure, cimetidine for stomach ulcers, or drugs like digoxin, diltiazem, quinidine, or beta-blockers for heart conditions. Mention if you are on anti-epileptic drugs like phenytoin, the antibiotic rifampicin, or combination treatment like quinupristin/dalfopristin. Also, disclose the use of cisapride, which aids in food passage through the digestive tract. Uncertainty exists regarding the interaction of Adipine with certain medications, such as erythromycin, ketoconazole, itraconazole, or fluconazole. Inform your doctor if you are taking HIV medications like indinavir, nelfinavir, ritonavir, or saquinavir, antidepressants like fluoxetine and nefazodone, or immunosuppressant drugs like tacrolimus. Additionally, mention the use of epilepsy medications like carbamazepine and valproic acid, as well as phenobarbital, primarily used for insomnia and anxiety. Avoid consuming grapefruit juice simultaneously or shortly after taking Adipine, as it can increase nifedipine blood levels. Do not take Adipine if you are pregnant, trying to conceive, or breastfeeding. Seek advice from your doctor or pharmacist before taking any medication. If Adipine causes dizziness or extreme fatigue, refrain from driving or operating machinery. Adipine contains lactose monohydrate; consult your doctor if you have sugar intolerance. For further information refer to the Patient Information Leaflet

Always adhere to your doctor’s instructions when taking Adipine. If uncertain about your dosage, consult your doctor or pharmacist for clarification. Adipine is formulated for once-daily administration, preferably in the morning. Swallow the tablet whole with a glass of water, avoiding grapefruit juice consumption. Refrain from breaking or chewing the tablets. For adults: The typical dosage for managing high blood pressure or preventing angina is 30 mg or 60 mg daily. Your doctor may adjust your dosage up to a maximum of 90 mg per day. Elderly patients may receive lower doses tailored to their needs. Do not discontinue medication without consulting your doctor. For further information refer to the Patient Information Leaflet

Take special care with Adipine and always inform your doctor if you: suffer from low blood pressure; experience chest pains when initiating Adipine treatment, contacting your doctor immediately; are diabetic, as your diabetes treatment may require adjustment; receive kidney dialysis and have very  high blood pressure with low blood volume; take other medications for high blood pressure (e.g. beta-blockers), in which case, if transitioning from a beta-blocker to nifedipine, gradual beta-blocker reduction should be discussed with your doctor; need to provide a urine sample, undergo a barium contrast X-ray, or have surgery; are male and have experienced unsuccessful attempts at fathering a child through in vitro fertilisation, as medicines like Adipine have been shown to impair sperm function. Under certain conditions, your doctor may deem it necessary to continue Adipine treatment during pregnancy,  particularly requiring careful consideration if magnesium sulphate injections are also administered. For further information refer to the Patient Information Leaflet